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KMID : 0941819930030020125
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Korean Journal of Clinical Pharmacy
1993 Volume.3 No. 2 p.125 ~ p.130
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Particle Size Distribution and Stability of Lipid Emulsion in Total Nutrient Admixtures
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박승미
장은주/신완균/이병구/이민화
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Abstract
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The particle size distribution and physical stability of commercial lipid emulsion inject, $intralipos^R$ before and after mixture with total parenteral nutrition(TPN) was tested. Three TNAs were prepared by adding intralipos to P-TPN, Neo-TPN and IVH-2 respectively. Particle size of fat emulsion in three TNA preparations were measured by using LPA-3000 photon correlater. Each TNAs was stored for 48 hours at 4^{circ}C;and;25^{circ}C. During storage, three TNAs showed the particle size in the range of 40-1000nm(about 100% of total fat) and in the range of 1000-8000nm(less than 0.005% of total fat). All TNAs were stable in terms of pH and visual appearance. The results showed that added lipid emulsion was stable for 48 hours at 4^{circ}C;and;25^{circ}C.
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KEYWORD
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